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KMID : 1034720190110010078
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Journal of Neurosonology and Neuroimaging
2019 Volume.11 No. 1 p.78 ~ p.83
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Decreased Bone Marrow Activity Measured by Using 18F-fluorodeoxyglucose Positron Emission Tomography among Patients with Cerebral Atherosclerosis
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Kim Jeong-Min
Lee Eun-Seong
Park Kwang-Yeol
Seok Ju-Won
Kwon Oh-Sang
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Abstract
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Background: We investigated bone marrow activity among patients with subclinical cerebral atherosclerosis.
Methods: Between January 2011 and December 2014, the patients who had undergone both brain computed tomography angiography (CTA) and whole body 18F-f luorodexoyglucose (FDG) positron emission tomography (PET) from health promotion center in a tertiary university hospital were included. Intracranial cerebral artery atherosclerosis was diagnosed using CTA, and bone marrow activity was measured using FDG PET from the 4th and 5th lumbar vertebral bodies. Cerebral artery vessel wall activity was measured from the cavernous portion of the internal carotid arteries (ICA). The maximal standardized uptake values of the vertebrae and target to background ratio of the vessel walls were compared by the Mann-Whitney U test among the patients with and without intracranial atherosclerosis.
Results: We identified 20 patients (mean age, 60.9±13.9 years; including six women) and seven of them were diagnosed with cerebral atherosclerosis. The cavernous ICA showed increased FDG uptake among the patients with cerebral atherosclerosis (1.08±0.24 vs. 0.91±0.18, p=0.02). The patients with cerebral atherosclerosis had significantly lower uptake values of FDG at the 4th (1.51±0.38 vs. 1.96±0.52, p=0.01) and the 5th (1.46±0.21 vs. 1.80±0.57, p=0.02) vertebrae.
Conclusion: Intracranial cerebral artery atherosclerosis is associated with decreased FDG uptake in lumbar vertebrae. Further studies are warranted to evaluate pathophysiological link between intracranial atherosclerosis and bone marrow activity.
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KEYWORD
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Cerebral atherosclerosis, Spine, Positron-emission tomography
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